The Pune to Khandwa bus route covers approximately 521 kms and takes about 14 hrs 53 mins. A total of 11 direct buses operated by 6 bus operators run on this route. The first bus departs at 17:50, and the last bus leaves at 21:30.
Major boarding points in Pune include Akurdi, Alandi Phata, Aundh, Bavdhan, Bhosari, Birla Hospital, Chandan Nagar, Chinchwad, Dange Chowk, Hadapsar, while common drop locations in Khandwa are Khandwa.
RTC and private operators such as Mansi Travels Khargone, Shri Sairam Travels offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 800 - INR 5000.00 depending on the bus type and features.



