The Coimbatore to Kayamkulam bus route covers approximately 293 kms and takes about 6 hrs 43 mins. A total of 29 direct buses operated by 13 bus operators run on this route. The first bus departs at 01:40, and the last bus leaves at 23:59.
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Major boarding points in Coimbatore include Chinniyampalayam, Eachanari, Ettimadai, Gandhipuram, Hopes College, KMCH, Karumathampatti, Lakshmi Mills, Neelambur, Omni Bus Stand, while common drop locations in Kayamkulam are Central Bus Stand Cbt, Kaniyapuram,, Others.
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RTC and private operators such as Surya Connect, Kallada Travels (Suresh Kallada), Maaruthi Travels, Krish Travels offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 353 - INR 3999.00 depending on the bus type and features.



