The Nagpur to Bhopal bus route covers approximately 352 kms and takes about 7 hrs 13 mins. A total of 50 direct buses operated by 30 bus operators run on this route. The first bus departs at 00:40, and the last bus leaves at 23:59.
Major boarding points in Nagpur include Ashirwad Theatre, Bole Petrol Pump, Butibori, Chatrapathi, Ganesh Pet, Gitanjali Talkies, Jagnade Chowk, LIC Chowk, Lohapul, Mankapur Stadium, while common drop locations in Bhopal are Airport Square, Alpana Talkies Hamidia Road, Ashoka Garden, Bhopal Railway Station, Idgah Square, Inter State Bus Terminal (ISBT), Lal Ghati, Mandideep Factory, Misrod, Nadra Bus Stand.
RTC and private operators such as Hans Travels (I) Private Limited, Bhopal Travels, New Royal Travels (Raipur), Gupta Travels Bhopal, NTC Nagpur Travels offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 400 - INR 5000.00 depending on the bus type and features.



