The Pondicherry to Karaikudi bus route covers approximately 289 kms and takes about 6 hrs 24 mins. A total of 4 direct buses operated by 4 bus operators run on this route. The first bus departs at 01:15, and the last bus leaves at 23:00.
Major boarding points in Pondicherry include Ariyankuppam, Avm College, Jipmer, Murungapakkam, New Bus Stand, Rajiv Gandhi Statue, while common drop locations in Karaikudi are New Bus Stand, Old Bus Stand.
RTC and private operators such as Vetri Travels, SBM TRAANSPORT offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 700 - INR 4199.00 depending on the bus type and features.



