The Sepon to Guwahati bus route covers approximately 396 kms and takes about 8 hrs 48 mins. A total of 26 direct buses operated by 15 bus operators run on this route. The first bus departs at 08:00, and the last bus leaves at 23:00.
Major boarding points in Sepon include Sepon Tinali, Sepon Tinali (Sepon), Sepon Tiniali, while common drop locations in Guwahati are ISBT Guwahati, Khanapara.
RTC and private operators such as Rayan Travels, BAIKUNTHA TRAVELS (UNDER ASTC), Trishul Transport Service, Bashudev Transline (Under ASTC), Christina Travels offer Volvo, AC, and non-AC seater and sleeper buses. Ticket prices on redBus range from INR 600 - INR 1100.00 depending on the bus type and features.



